Caffeine, a compound found in coffee, has been relied upon for generations to help increase energy levels and heighten alertness. Along with these benefits, caffeine comes with some negative effects to your body as well including anxiety, headaches, and an effect on blood pressure. Additionally, caffeine has been found to change the way your brain responds to inositol.
A small amount of caffeine—even 5mg—can minimize the activity of inositol receptors by up to three times the norm. Caffeine has also shown to deplete inositol within the body by affecting the way the body absorbs it through the diet. If you’re taking inositol supplements, particularly for therapeutic purposes, try to limit your caffeine intake as much as possible to gain the most benefit from the supplement.